MimetikOss 3D, the Personalized Biomimetic Synthetic Bone Graft
Above all, Mimetis Biomaterials is undeniably the first and only to print patient-specific biomimetic synthetic bone graft in 3D. It is important to realize that Mimetis engineers use the patient’s bone defect’s medical images to design and print a perfectly customized bone graft.
Most important, the biomimetic synthetic bone graft is not sintered. In other words, we do not subject it to any extreme temperatures hardening process. With this purpose in mind, its structure and composition are similar to the bone mineral phase, exhibiting a high specific surface and multi-scale porosity.
This is why MimetikOss 3D is perfect for vertical bone augmentations and complex geometries.
Overall, MimetikOss 3D is biomimetic synthetic bone graft that is custom made. In other words, it is based on the anatomy of the patient. Thus, this allows a perfect fit of the graft with the bone defect even for complex geometries.
The nano-, micro- and macro-porosity favors the adsorption of proteins and cell adhesion. Therefore, it facilitates the colonization of the graft by bone cells. Also, it supports the vascularization and the growth of newly formed bone.
Also, at the macrometric level, the adjustments of the impression allow to obtain an open and interconnected porosity that favors the vascularization and the colonization of the tissues.
Biomimetic hydroxyapatite compound deficient in calcium and β-TCP. This is why the body recognizes it as the patient’s own bone, so the use of the graft presents no risk of rejection or infection.
During the manufacturing process, the precise control of the architecture of the porosity. Specifically, the size of the interconnected network of pores. Further, it allows adapting the response of the body to the bone graft.
Certainly, we focus on offering bone grafts that adapt exactly to the anatomy of the patient. However, and if strictly necessary, the surgeon can further modify the graft during surgery, with a surgical handpiece or other cutting tools.
With this purpose in mind, MimetikOss is regulated for the following indications:
- Vertical bone augmentations
- Complex geometries
- Large critical size defects
MimetikOss Granules, the Biomimetic Synthetic Option
We at Mimetis manufacture MimetikOss under hydrothermal processes that mimic the natural bone’s structure and composition.
Indeed, MimetikOss Granules is the 4th and latest generation biomimetic synthetic bone graft that allows rapid creation of a highly vascularized bone tissue. Furthermore, it integrates exceptionally well with the surrounding soft tissue, due unquestionably to its nano-, micro- and macro-porosity.
As a result, not only does it preserve bone volume, but it also activates natural bone regeneration. Therefore, MimetikOss covers the most common indications up to the most challenging ones.
To point out, MimetikOss is the only biomimetic synthetic bone graft on the market. Indeed, it is similar in shape, structure and composition to the mineral phase of human bone. The reasons for that include:
- 80% biomimetic calcium-deficient hydroxyapatite (CDHA)
- 20% biomimetic beta-tricalcium phosphate (β-TCP)
In like fashion, MimetikOss Granules is readily available in two sizes:
- S (0.2 – 1 mm)
- M (1 – 2 mm)
In this case, MimetikOss replicates the structure and composition of the mineral part of the bone. Consequently, it triggers consequently the bone cells to recognize it as natural bone.
In particular, MimetikOss’ radioopacity is identical to natural bone’s. The reason for that is its similarity in structure and composition.
Most important, MimetikOss is particularly highly hydrophilic for easier user-handling.
In the same way, MimetikOss’ spheroidal morphology avoids stacking over time.
- Sinus lift
- Alveolar ridge augmentation
- Peri-implant tissue preservation
- Alveolar ridge preservation
- Infraosseous / supra-osseous / intraosseous defects
- Horizontal and vertical interradicular bone loss
- Maxillofacial plastic surgery
- Periodontal filling
- Maxillary distraction
Frequently Asked Questions about Synthetic Biomimetic Bone Grafts
Biomimicry and Differentiation
By all means, a biomimetic bone graft reproduces the structure, composition, and topography of the mineral phase of natural bone. Thus, the graft then quickly incorporates into the bone and enters; as a result, the bone remodeling process, until it eventually achieves a stable and complete regeneration of the defect. This is made possible thanks to its biomimetic macro-, micro-, and nano-porosity structures, resulting in the natural growth of hydroxyapatite nanocrystals. Additionally, its high porosity allows for easy hydration and handling of the product, due to its affinity with water and aqueous solutions.
In summary, biomimicry solves the lack of synchronization between the biomaterial’s degradation and new bone formation, observed with the current solutions.
Therefore, the main difference between MimetikOss and other synthetic grafts is that MimetikOss is basically made of hydroxyapatite nanocrystals that reproduce the structure, topography, and natural bone composition. Initially, these nanocrystals are obtained thanks to a manufacturing process that follows natural physiological conditions. In contrast, other current synthetic biomaterials are prepared at high temperatures, and consequently, they do not resemble the bone mineral phase sufficiently well to be remodeled and included in the physiological bone cycle.
Composition and Advantages
Unquestionable, MimetikOss is the first biomimetic bone graft. Specifically, it allows rapid, stable, and natural bone regeneration of bone defects. Additionally, it is the first 4th generation bone graft capable of interacting with the recipient tissue to ensure clinical success. Overall, MimetikOss is composed of 80% calcium-deficient hydroxyapatite and 20% β-TCP.
Safety and Manufacturing
Altogether, MimetikOss is CE certified. In other words, it has successfully passed all the necessary tests required by the European Union. Besides, the manufacturing process of MimetikOss is strictly controlled. On top of that, it ensures high quality and safety standards because it undergoes multiple purity controls of the raw materials. Additionally, the biomaterial complies with biocompatibility standards, sterility, and the biomimetic characteristics that allow it to achieve a significantly better clinical result.
Furthermore, MimetikOss also complies particularly with ISO 13485 of Medical Equipment. Specifically, this directive sets out the requirements of having an internationally recognized quality management system (QMS) for medical device manufacturers.
MimetikOss is manufactured in a highly controlled, clean and pure environment (ISO 7 white room). More specifically, It complies with the necessary regulations, and accordingly is produced by qualified personnel specialized in biomaterials and tissue engineering.
Using MimetikOss: How and When
MimetikOss is useful for different applications such as increased lateral defects and vertical bone defects; furthermore it can be used in composite, lateral-vertical defects.
The time of regeneration of the bone defect undoubtedly depends on several parameters, such as the type of bone defect, the location, and the patient’s state of health. In general, in a simple alveolar preservation indication, 4-6 months of regeneration are enough to have a neo-formed vascularized bone, with adequate mechanical stability for dental implant placement.
That will evidently depend on the size of the defect. For small defects, we recommend using size S and size M for the larger cavities. However, Mimetis observes that the clinician makes this decision when planning the surgery, or when opening the defect.
For correct bone regeneration, MimetikOss must be contained in the affected area, in order to prevent the connective tissue from growing inward. For instance, resorbable or non-resorbable membranes, plugs, sponges, or other tools can help hold the MimetikOss granules.
MimetikOss can be hydrated equally with water or the patient’s own blood, or even with sterile physiological saline.
Evidently, the time of regeneration of the bone defect depends alternatively on several parameters, such as the type of bone defect, the location, and the patient’s state of health. In general, in a simple alveolar preservation indication, 4-6 months of regeneration are enough to have a neo-formed vascularized bone, unquestionably with adequate mechanical stability for dental implant placement.
Point often overlooked, MimetikOss has a radiopacity similar to that of bone. Consequently, after its placement, it is easier to differentiate it in an X-ray scanner against soft tissue.
It is important to realize that MimetikOss is uniquely recognized as bone by the patient’s cells and by the immune system. Thus, it allows it to be included in the cycle of physiological bone remodeling. As a matter of fact, the physiological integration of MimetikOss provides key clinical aspects, such as the synchronization between vascularized bone formation and the degradation of the biomaterial, hand-in-hand with the patient’s metabolism, ensuring, in the same fashion the defect’s volumetric stability.