Personalized Biomimetic Synthetic Bone Graft
Above all, Mimetis Biomaterials is undeniably the first and only to print patient-specific biomimetic synthetic bone graft in 3D. It is important to realize that Mimetis engineers use the patient’s bone defect’s medical images to design and print a perfectly customized bone graft.
Most important, the biomimetic synthetic bone graft is not sintered. In other words, we do not subject it to any extreme temperatures hardening process. With this purpose in mind, its structure and composition are similar to the bone mineral phase, exhibiting a high specific surface and multi-scale porosity.
This is why MimetikOss 3D is perfect for vertical bone augmentations and complex geometries.
Overall, MimetikOss 3D is biomimetic synthetic bone graft that is custom made. In other words, it is based on the anatomy of the patient. Thus, this allows a perfect fit of the graft with the bone defect even for complex geometries.
The nano-, micro- and macro-porosity favors the adsorption of proteins and cell adhesion. Therefore, it facilitates the colonization of the graft by bone cells. Also, it supports the vascularization and the growth of newly formed bone.
Also, at the macrometric level, the adjustments of the impression allow to obtain an open and interconnected porosity that favors the vascularization and the colonization of the tissues.
Biomimetic hydroxyapatite compound deficient in calcium and β-TCP. This is why the body recognizes it as the patient’s own bone, so the use of the graft presents no risk of rejection or infection.
During the manufacturing process, the precise control of the architecture of the porosity. Specifically, the size of the interconnected network of pores. Further, it allows adapting the response of the body to the bone graft.
Certainly, we focus on offering bone grafts that adapt exactly to the anatomy of the patient. However, and if strictly necessary, the surgeon can further modify the graft during surgery, with a surgical handpiece or other cutting tools.
With this purpose in mind, MimetikOss is regulated for the following indications:
- Vertical bone augmentations
- Complex geometries
- Large critical size defects
Biomimetic Synthetic Option
We at Mimetis manufacture MimetikOss under hydrothermal processes that mimic the natural bone’s structure and composition.
Indeed, MimetikOss Granules is the 4th and latest generation biomimetic synthetic bone graft that allows rapid creation of a highly vascularized bone tissue. Furthermore, it integrates exceptionally well with the surrounding soft tissue, due unquestionably to its nano-, micro- and macro-porosity.
As a result, not only does it preserve bone volume, but it also activates natural bone regeneration. Therefore, MimetikOss covers the most common indications up to the most challenging ones.
To point out, MimetikOss is the only biomimetic synthetic bone graft on the market. Indeed, it is similar in shape, structure and composition to the mineral phase of human bone. The reasons for that include:
- 80% biomimetic calcium-deficient hydroxyapatite (CDHA)
- 20% biomimetic beta-tricalcium phosphate (β-TCP)
In like fashion, MimetikOss Granules is readily available in two sizes:
- S (0.2 – 1 mm)
- M (1 – 2 mm)
In this case, MimetikOss replicates the structure and composition of the mineral part of the bone. Consequently, it triggers consequently the bone cells to recognize it as natural bone.
In particular, MimetikOss’ radioopacity is identical to natural bone’s. The reason for that is its similarity in structure and composition.
Most important, MimetikOss is particularly highly hydrophilic for easier user-handling.
In the same way, MimetikOss’ spheroidal morphology avoids stacking over time.
- Sinus lift
- Alveolar ridge augmentation
- Peri-implant tissue preservation
- Alveolar ridge preservation
- Infraosseous / supra-osseous / intraosseous defects
- Horizontal and vertical interradicular bone loss
- Maxillofacial plastic surgery
- Periodontal filling
- Maxillary distraction